International Journal of Physical Distribution & Logistics Management, v. 44, n. 7, pp. 540-558. Abstract Purpose: The purpose of this paper is to investigate the issue of efficiency in the Brazilian motor carrier industry, which has undergone significant transformations since the economy deregulation in the mid-1990s. The main research objective is to determine whether or not different types of cargoes and geographic regions serviced significantly impact trucking managerial efficiency levels. Design/methodology/approach: Research objectives are accomplished by applying a two-stage data envelopment analysis model with bootstrapped estimates. Based on an unbalanced panel model, secondary data from the annual study published by Transporte Moderno (years 2002-2010) were collected and analyzed. Findings: Results support anecdotal evidence regarding a heterogeneous impact of cargo mix and route mix on efficiency levels. Research limitations/implications: A major limitation of this work concerns the fact of working with secondary data instead of primary data, especially with respect to the set of inputs and outputs used in the analysis, which may not cover all aspects relevant to building an efficiency frontier. Despite this limitation, the study has made an important contribution in its use of panel data to demonstrate the impacts of different types of cargoes and geographic regions serviced on managerial efficiency levels in the trucking industry. Practical implications: Managerial impacts in terms of mergers and acquisitions are addressed. Originality/value: The contribution of this study is twofold. On the theoretical side, a valuable scale for the measurement of managerial efficiency was built and validated, representing an index toward the most productive cargo/route mix. On the other hand, the managerial implication of this possibility of measuring the efficiency levels is that motor carriers can use it as a basis for establishing future action plans.